Structural investigation of multivalent carbohydrate-protein interactions using synthetic biomolecules.
نویسنده
چکیده
Understanding multivalent carbohydrate-protein interactions at the molecular level requires access to structural details of these important biological recognition processes. Recent developments toward this goal comprise the use of conformationally defined molecular rulers in combination with binding assays, crystallographic investigation of complexes of multivalent ligands and their target proteins, and distance measurements in the nanometer range by EPR spectroscopy.
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ورودعنوان ژورنال:
- Current opinion in chemical biology
دوره 17 6 شماره
صفحات -
تاریخ انتشار 2013